Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections
Identifieur interne : 005926 ( Main/Exploration ); précédent : 005925; suivant : 005927Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections
Auteurs : Sasisekhar Bennuru ; Grace Maldarelli ; V. Kumaraswami ; Amy D. Klion ; Thomas B. NutmanSource :
- The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Angiopoïétines (métabolisme), Angiopoïétines (sang), Animaux, Doxycycline (usage thérapeutique), Facteur de croissance fibroblastique de type 2 (métabolisme), Facteur de croissance fibroblastique de type 2 (sang), Facteurs de croissance endothéliale vasculaire (métabolisme), Facteurs de croissance endothéliale vasculaire (sang), Filaricides (usage thérapeutique), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Inde (épidémiologie), Jeune adulte, Mali (épidémiologie), Protéines angiogéniques (métabolisme), Protéines angiogéniques (sang), Sujet âgé, Wuchereria bancrofti.
- MESH :
- métabolisme : Angiopoïétines, Facteur de croissance fibroblastique de type 2, Facteurs de croissance endothéliale vasculaire, Protéines angiogéniques.
- parasitologie : Filariose lymphatique.
- sang : Angiopoïétines, Facteur de croissance fibroblastique de type 2, Facteurs de croissance endothéliale vasculaire, Filariose lymphatique, Protéines angiogéniques.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Doxycycline, Filaricides.
- épidémiologie : Filariose lymphatique, Inde, Mali.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Humains, Jeune adulte, Sujet âgé, Wuchereria bancrofti.
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Angiogenic Proteins (blood), Angiogenic Proteins (metabolism), Angiopoietins (blood), Angiopoietins (metabolism), Animals, Doxycycline (therapeutic use), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Fibroblast Growth Factor 2 (blood), Fibroblast Growth Factor 2 (metabolism), Filaricides (therapeutic use), Humans, India (epidemiology), Mali (epidemiology), Middle Aged, Vascular Endothelial Growth Factors (blood), Vascular Endothelial Growth Factors (metabolism), Wuchereria bancrofti, Young Adult.
- MESH :
- chemical , blood : Angiogenic Proteins, Angiopoietins, Fibroblast Growth Factor 2, Vascular Endothelial Growth Factors.
- chemical , metabolism : Angiogenic Proteins, Angiopoietins, Fibroblast Growth Factor 2, Vascular Endothelial Growth Factors.
- chemical , therapeutic use : Doxycycline, Filaricides.
- geographic , epidemiology : India, Mali.
- blood : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Animals, Humans, Middle Aged, Wuchereria bancrofti, Young Adult.
Abstract
Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoeitins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for
Url:
DOI: 10.4269/ajtmh.2010.10-0039
PubMed: 20889885
PubMed Central: 2946762
Affiliations:
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Le document en format XML
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Kumaraswami</name></author><author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Angiogenic Proteins (blood)</term><term>Angiogenic Proteins (metabolism)</term><term>Angiopoietins (blood)</term><term>Angiopoietins (metabolism)</term><term>Animals</term><term>Doxycycline (therapeutic use)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Fibroblast Growth Factor 2 (blood)</term><term>Fibroblast Growth Factor 2 (metabolism)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>India (epidemiology)</term><term>Mali (epidemiology)</term><term>Middle Aged</term><term>Vascular Endothelial Growth Factors (blood)</term><term>Vascular Endothelial Growth Factors (metabolism)</term><term>Wuchereria bancrofti</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angiopoïétines (métabolisme)</term><term>Angiopoïétines (sang)</term><term>Animaux</term><term>Doxycycline (usage thérapeutique)</term><term>Facteur de croissance fibroblastique de type 2 (métabolisme)</term><term>Facteur de croissance fibroblastique de type 2 (sang)</term><term>Facteurs de croissance endothéliale vasculaire (métabolisme)</term><term>Facteurs de croissance endothéliale vasculaire (sang)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Inde (épidémiologie)</term><term>Jeune adulte</term><term>Mali (épidémiologie)</term><term>Protéines angiogéniques (métabolisme)</term><term>Protéines angiogéniques (sang)</term><term>Sujet âgé</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Angiogenic Proteins</term><term>Angiopoietins</term><term>Fibroblast Growth Factor 2</term><term>Vascular Endothelial Growth Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Angiogenic Proteins</term><term>Angiopoietins</term><term>Fibroblast Growth Factor 2</term><term>Vascular Endothelial Growth Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>India</term><term>Mali</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Angiopoïétines</term><term>Facteur de croissance fibroblastique de type 2</term><term>Facteurs de croissance endothéliale vasculaire</term><term>Protéines angiogéniques</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Angiopoïétines</term><term>Facteur de croissance fibroblastique de type 2</term><term>Facteurs de croissance endothéliale vasculaire</term><term>Filariose lymphatique</term><term>Protéines angiogéniques</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Doxycycline</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Inde</term><term>Mali</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Humans</term><term>Middle Aged</term><term>Wuchereria bancrofti</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Humains</term><term>Jeune adulte</term><term>Sujet âgé</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term><term>Mali</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoeitins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for <italic>Wolbachia</italic>. Our data support the concept that filarial infection <italic>per se</italic> is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with <italic>Wuchereria bancrofti</italic> infection.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><name sortKey="Maldarelli, Grace" sort="Maldarelli, Grace" uniqKey="Maldarelli G" first="Grace" last="Maldarelli">Grace Maldarelli</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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